Regentis International;Université De Reims Champagne-Ardenne;Centre National de la Recherche Scientifique
发明人:
HORNEBECK, William,ATTIA, Joan,LORIMIER, Sandrine,ANTONICELLI, Frank
申请号：
ES13712827
公开号：
ES2631030T3
申请日:
2013.01.31
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Bifunctional peptide capable of activating the synthesis of collagen and inhibiting the production of matrix metalloproteinases, characterized in that it has a sequence containing three peptide parts A, B and C: - the first peptide part A corresponding to a repeated hexapeptide at least three times, said part A being able to bind to a receptor protein that binds elastin to stimulate collagen synthesis, and presenting the sequence X1-Gly-X2-X3-Pro-Gly, where: or X1 corresponds to any amino acid, or X2 corresponds to an amino acid chosen from Val, Thr, Gln, Ala, Leu, or X3 corresponds to an amino acid chosen from Ala, Leu, Ile, - the second peptide part B corresponding to a tetrapeptide capable of acting as a competitive inhibitor of urokinase protease and if cleaved by said protease, and presenting the sequence Arg-Y1-Arg-Y2, where Y1 and Y2 each correspond to an amino acid chosen from Ser, Tyr, Gly, Ala, Arg, Val, Leu, and - the third peptide part C corresponds to a tripeptide that occupies at least one active site of the matrix metalloproteinases to allow an inhibition of said proteinases, and presenting the sequence Z1-Ile-Z2, where: or Z1 corresponds to an amino acid chosen from Gly , Ile, Leu and Z2 correspond to an amino acid chosen from Leu, Phe, Ala, Ile, Val.Péptido bifuncional capaz de activar la síntesis de colágeno y de inhibir la producción de metaloproteinasas de matriz, caracterizado por que presenta una secuencia que contiene tres partes peptídicas A, B y C: - correspondiendo la primera parte peptídica A a un hexapéptido repetido al menos tres veces, siendo capaz dicha parte A de unirse a una proteína receptora que enlaza la elastina para estimular la síntesis de colágeno, y presentando la secuencia X1-Gly-X2-X3-Pro-Gly, donde: o X1 corresponde a un aminoácido cualquiera, o X2 corresponde a un aminoácido elegido entre Val, Thr, Gln, Ala, Leu, o X3 corresponde a un aminoácido elegido entre Ala, Leu, Ile, - correspondiendo la segunda parte peptídica B a
