The present invention provides an extract of adlay bran comprising an C1 to C7 alcohol extract of adlay bran (A) and a carbon dioxide supercritical fluid extract of adlay bran (B). Preferably, the extract of adlay bran has an effect in treating skin and/or subcutaneous tissue disorders.本發明係提供薏苡子麩皮之萃取物,其包含薏苡子麩皮之具有1至7碳數之醇萃取物(A)及薏苡子麩皮之二氧化碳超臨界流體萃取物(B)。較佳地,該薏苡子麩皮之萃取物具有治療皮膚及/或皮下組織疾病之效果。