(57)< Abstract > This invention offers the antibody which the hydrolysis of -amiroido the catalyst is done with the amide connection which is decided beforehand. This antibody during hydrolysis with the amide connection which is decided beforehand, connects to the transition state analog which imitates a transition state where the - amyloid takes preferentially. The unique antibody which is offered, the residue includes the antibody which hydrolysis of amyloid connection between 39 of -amiroido and 40, 40 and 41, and 41 and 42 the catalyst is done. This antibody features the ability the catalyst to do hydrolysis of ability and -amiroido which cross blood brain baria, to be kuta the antibody which is converted it offers. In addition, in order to reduce the level of -amiroido which is circulating in order to reduce the amyloid level inside the brain, in order to prevent the formation of amyloid unevenness inside the brain, and in order to disassemble amyloid unevenness, it offers also the method of being segregated the separation - amyloid in the blood style. In addition lastly as for this invention, it offers also the method of forming the antibody the star chin analog which imitates the configuration of hydrolysis transition state of the polypeptide or the animal by the immunity impression work doing with the antigen which consists of epitopu which utilizes the peptide Symphyla being similar body which is restored.本発明は、予め定めたアミド結合でβ-アミロイドの加水分解を触媒する抗体を提供する。この抗体は予め定めたアミド結合での加水分解中に、β-アミロイドがとる遷移状態を模する遷移状態類似体に優先的に結合する。提供される特異的抗体は、β-アミロイドの残基39と40、40と41、および41と42の間のアミロイド結合の加水分解を触媒する抗体を含む。本抗体は血液脳バリアーをわたる能力およびβ-アミロイドの加水分解を触媒する能力を特徴とする、べクター化された抗体お提供する。また、脳内のアミロイドレベルを下げるために、循環しているβ-アミロイドのレベルを下げるために、脳内のアミロイド斑の形成を防止するために、そしてアミロイド斑を分解するために、血流中の遊離β-アミロイドを隔絶する方法も提供する。最後に本発明はまた、ポリペプチドの加水分解遷移状態の立体配置を模するスタチン類似体または還元されたペプチド結合類似体を利用するエピトープから成る抗原で動物を免疫感作することにより抗体を生成する方法も提供する。
