The present invention provides substituted pyrazolo-heterocycles having thegeneral structure of formula I (I). Thestructures of rings A and B and substituents R a, R b and R c are described inthe specification. Also provided are pharmaceuticallyacceptable salts, acid salts, hydrates, solvates and stereoisomers of thecompounds of formula I. The compounds are useful asmodulators of cannabinoid receptors and for the prophylaxis, treatment andinhibition of cannabinoid receptor- associated diseasesand conditions, such as pain, inflammation and pruritis.
