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SOLID PREPARATION INCLUDING ANTIOXIDANT
专利权人:
DAIICHI SANKYO COMPANY; LIMITED
发明人:
Shinichiro TAJIRI,Jin HISAZUMI,Shinji YOSHINAGA,Hiroyuki FUJIMORI,Hiroaki ARAI
申请号:
US15559573
公开号:
US20180042878A1
申请日:
2016.03.17
申请国别(地区):
US
年份:
2018
代理人:
摘要:
An object of the present invention is to provide [(1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid monobenzenesulfonate as a stabilized pharmaceutical solid preparation, and also to provide a method for preparing the stabilized pharmaceutical solid preparation. The object can be attained by a pharmaceutical solid preparation comprising [(1R,5S,6S)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid monobenzenesulfonate which is compound represented by the following formula (I) in combination with (i) one or two or more excipients, (ii) one or two or more disintegrants, and (iii) a specific antioxidant.
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