The present invention relates to the compounds having estrogenic activity selected from the group consisting of Loliolide, (4S, 6S)-4-Hydroxy-6-nonadecyl-tetrahydro-pyran-2-one, (4R, 6S)-4-Hydroxy-6-nonadecyl-tetrahydro-pyran-2-one and analogues thereof. The compounds of the present invention are selective estrogen receptor modulator which can selectively activate ER &bgr； , and simultaneously express high estrogenic activity which can be applied to a medical or food compositions for improving symptoms caused by estrogen deficiency.本發明係關於一種具雌激素活性之化合物，其係選自黑麥草內酯(Loliolide)、(4S,6S)-4-羥基-6-十九烷基-四氫吡喃-2-酮((4S,6S)-4-Hydroxy-6-nonadecyl-tetrahydro-pyran-2-one)、(4R,6S)-4-羥基-6-十九烷基-四氫吡喃-2-酮((4R,6S)-4-Hydroxy-6-nonadecyl-tetrahydro-pyran-2-one)以及其化學結構類似物所組成之族群。該些化合物係為可選擇性活化ERβ之選擇性雌激素受體調節劑(SERM)，同時可展現出極佳的雌激素活性，藉以用於改善缺乏雌激素所引發症狀之醫藥組成物或食品組成物。
