Liang Liu,David Ward,Elaine Lai-Han Leung,Xiao Jun Yao,Vincent Kam-Wai Wong,Lian-Xiang Luo
申请号：
US15337293
公开号：
US09861623B1
申请日:
2016.10.28
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides methods for treatment of a RAS-positive disease, in particular KRAS-positive non-small cell lung cancer as well as a method for potentiating the apoptotic activity of a PDEδ inhibitor by combining the PDEδ inhibitor with a direct autophagy inhibitor. The PDEδ inhibitor is preferably, but not exclusively, deltarasin, and the direct autophagy inhibitor is in particular 3-methyladenine. Further provided by the present invention are a kit and a pharmaceutical composition comprising the PDEδ inhibitor and a direct autophagy inhibitor. The methods of the present invention in particular provide a new treatment option for RAS-positive diseases such as KRAS-positive non-small cell lung cancer allowing for an increased apoptotic activity of the PDEδ inhibitor by simultaneously blocking its “tumor protective” autophagy.
