process of radionuclide labeling of murine or human, monoclonal or polyclonal anti-tumor necrosis factor associated with diseases whose pathophysiology involves tumor necrosis factor； reagent for diagnosis "in vivo" and / or "in vitro" based on murine or human antibodies, monoclonal or polyclonal anti-tumor necrosis factor associated with radionuclides； diagnostic methods "in vitro" and / or "in vivo" of diseases whose physiotopagenia involves tumor necrosis factor using the reagent thus obtained and kit for diagnosing diseases whose pathophysiology involves tumor necrosis factor based on said
Bianca Gutfilen,Flávia Paiva Proença Lobo Lopes,Lea Mirian Barbosa da Fonseca,Sergio Augusto Lopes de Souza
申请号：
BRPI1003970
公开号：
BRPI1003970B1
申请日:
2010.10.29
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
process of radionuclide labeling of murine or human, monoclonal or polyclonal anti-tumor necrosis factor associated with diseases whose pathophysiology involves tumor necrosis factor； reagent for diagnosis "in vivo" and / or "in vitro" based on murine or human antibodies, monoclonal or polyclonal anti-tumor necrosis factor associated with radionuclides； diagnostic methods "in vitro" and / or "in vivo" of diseases whose pathophysiology involves tumor necrosis factor using the reagent thus obtained and kit for diagnosing diseases whose pathophysiology involves tumor necrosis factor based on said reagent. the present invention relates to a radionuclide staining process for murine or human, monoclonal or polyclonal anti-tumor necrosis factor antibodies, as well as for the diagnostic reagent "in vivo" or "in vitro" based on anti-tumor antibodies tumor necrosis factor, murine or human, monoclonal or polyclonal marked with radionuclides, its use for diagnosis, the 'in vitro' and 'in vivo' diagnosis method of diseases whose pathophysiology involves the tumor necrosis factor and the diagnostic kit immunological diseases using said reagent.processo de marcação com radionuclídeos de anticorpos murinos ou humanos, monoclonais ou policlonais anti-fator de necrose tumoral associados a doenças cuja fisiopatogenia envolva fator de necrose tumoral； reagente para diagnóstico "in vivo" e/ou "in vitro" a base de anticorpos murinos ou humanos, monoclonais ou policlonais anti-fator de necrose tumoral associados a radionuclídeos； métodos de diagnóstico "in vitro" e/ou "in vivo" de doenças cuja fisiopatogenia envolva fator de necrose tumoral utilizando o reagente assim obtido e kit para diagnóstico de doenças cuja fisiopatogenia envolva fator de necrose tumoral a base do referido reagente. a presente invenção refere-se a um processo de marcação com radionuclídeos de anticorpos murinos ou humanos, monoclonais ou policlonais anti-fator de necrose tumoral, bem como ao reagente para diagnóstic
