ALEXANDER V. MAYWEG,BENOIT HORNSPERGER,BERND KUHN,HANS P. MAERKI,JOHANNES AEBI,KURT AMREIN,MINGWEI ZHOU,PETER MOHR,WENMING CHEN,XUEFEI TAN,Yongfu Liu,ZHANGUO WANG
申请号：
BR112014013136
公开号：
BR112014013136A2
申请日:
2012.11.27
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
Summary New Bicyclic Dihydroisoquinoline-1-One Derivatives The invention provides novel compounds having the general formula (i) (i) a5a1nor1r2r3r4r5r7a4na3a2 () wherein r1, r2, r3, r4¸r5, r6, a1, a2, a3, a4 , a5 and n are as described herein, compositions including the compounds and methods of using the compounds as aldosterone synthase inhibitors (cyp11b2 or cyp11b1) for the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and cushing syndrome. .resumo novos derivados de dihidroisoquinolina-1-ona bicíclicos a invenção provê compostos novos tendo a formula geral (i) (i) a5a1nor1r2r3r4r5r7a4na3a2( )n em que r1, r2, r3, r4¸ r5, r6, a1, a2, a3, a4, a5 e n são como descrito aqui, composições incluindo os compostos e métodos de utilizar os compostos como inibidores de aldosterone synthase (cyp11b2 ou cyp11b1) para o tratamento ou profilaxia de doença renal crônica, insuficiência cardíaca congestiva, hipertensão, aldosteronismo primário e síndrome de cushing.
