AWESH KUMAR YADAV DR;GOPAL RAI DR;SANTRAM LODHI DR;Mr Ashish Garg;ALOK PAL JAIN DR
发明人:
AWESH KUMAR YADAV DR,Dr Awesh Kumar Yadav,GOPAL RAI DR,Dr Gopal Rai,SANTRAM LODHI DR,Dr Santram Lodhi,Mr Ashish Garg,Mr Ashish Garg,ALOK PAL JAIN DR,Dr Alok Pal Jain
申请号：
IN3124/MUM/2015
公开号：
IN2015MU03124A
申请日:
2015.08.18
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The present invention relates to a method for targeted effectively delivering an anticancer drug (i.e. 5-FU) into cancer cells by encapsulated the anticancer drug to heparin anchored cellulose acetate phthalate (HEC) nanoparticles. HEC nanoparticles according to the present invention, HEC nanoparticles were selectively deliver 5-FU to lung cancer as heparin and other related compounds have been proved to modulate the activity of Tumor Necrosis Factor and NF-?B, which are involved in apoptotic cell death and heparin as ligands for Anaplastic Lymphoma Kinase (ALK). HEC nanoparticles can also allow for controlled and/or sustained release of 5-FU in vivo.
