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HLA-INDEXED REPOSITORY OF iPSCS AND iPSC-DERIVED STEM CELLS, AND RELATED SYSTEMS AND METHODS
专利权人:
Orig3n; Inc.
发明人:
Robin Y. Smith,Marcie A. Glicksman
申请号:
US16492690
公开号:
US20200051666A1
申请日:
2018.03.14
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Described herein is a managed, indexed repository of hematopoietic stem cell (HSC) lines and/or blood progenitor cell lines derived from induced pluripotent stem cells (iPSCs) (or embryoid bodies formed from iPSCs), wherein each of the HSC lines, blood progenitor cell lines, embryoid bodies, and/or iPSC lines has corresponding data comprising a set of characterized HLA loci, said corresponding data being stored in a searchable database for retrieval of one or more matching physical cell lines upon query. The repository comprises an HLA-indexed bank of iPSCs, embryoid bodies, HSCs, and/or blood progenitor cells for each of a set of HLA types, for identification and provision of allogeneic cell lines suitable for transplantation to reestablish hematopoietic function in patients with damaged, diseased, or otherwise abnormal bone marrow and/or immune system.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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