An operating head for a full thickness resection system includes a first optical device disposed on a distal portion thereof and having a viewing area extending distally of the distal portion and a working chamber extending within an exterior wall of the operating head, a first portion of the exterior wall being moveable with respect to a second portion thereof to selectively open the working chamber to an exterior of the operating head. Furthermore, the operating head includes a second optical device mounted within the working chamber with a viewing area of the second optical device extending distally therefrom.
