James Dodge;Lamya Shihabuddin;Marco Passini;Seng H. Cheng;Catherine O'Riordan
发明人:
James Dodge,Lamya Shihabuddin,Marco Passini,Seng H. Cheng,Catherine O'Riordan
申请号：
US11934148
公开号：
US10744210B2
申请日:
2007.11.02
申请国别(地区):
US
年份:
2020
代理人:
摘要：
This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention provides a method to deliver a transgene to a subject's spinal cord by administering a recombinant neurotropic viral vector containing the transgene. The viral vector delivers the transgene to a region of the deep cerebellar nuclei region of the brain. Also provided are compositions and methods to deliver a transgene to a subject's spinal cord by administering a recombinant neurotropic viral vector containing the transgene to the motor cortex region of the subject's brain.
