A drug coated balloon (DCB) catheter (4) has a connector (8), a shaft (20) extending from a proximal end (24) to a distal end (28) along an axial direction (X-X) and has a guidewire lumen (32) and an inflation lumen (36), the shaft being connected to the connector (8) on said proximal end (24), wherein the shaft (20) being provided with an inflatable balloon (48), fluidically connected with said inflation lumen (36) in order to be selectively inflated and/or deflated. Advantageously, the balloon (48) is coated with a drug to be delivered on a target lesion, an external wall (52) of the shaft (20), opposite to said lumens (32,36), is covered with a lubricant, and said guidewire lumen (32) is internally covered with a lubricant.
