New spiroepoxide tetrahydrobenzo-triazoles and -imidazoles and their use as MetAP-II inhibitors

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专利权人:

发明人:

申请号：

EP12006666.7

公开号：

EP2711367A1

申请日:

2012.09.22

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

The present invention relates to new spiroepoxide tetrahydrobenzo-triazole and - imidazole compounds, a method for their production and their use as MetAP-II inhibitors, which are particularly useful as inhibitors of angiogenesis. The compounds are characterized by formula (I)X=CorNR1 = OC(O)R2 where R2 is alkyl, cycloalkyl, aryl, heteroaryl, or cinnamyl orR1 = OC(O)NHR3 where R3 is alkyl, cycloalkyl, aryl, or heteroarylorR1 = NHC(O)OR4 where R4 is alkylorR1 = OH, NH2R5 = alkyl, cycloalkyl, CH2R6 where R6 is aryl or heteroaryl

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