USE OF AN ANTIBIOTIC PEPTIDE FROM VENOMS OF THE SCORPION CENTRUROIDES SUFFUSUS SUFFUSUS AND PHARMACEUTICAL COMPOSITIONS OBTAINED FROM COMMERCIAL ANTIBIOTICS.
LOURIVAL DOMINGOS POSSANI POSTAY,GERARDO ALFONSO CORZO BURGUETE,FRANCIA GARCÍA GARCÍA,ELBA CRISTINA VILLEGAS VILLARREAL
申请号：
MX2011005274
公开号：
MX343126B
申请日:
2011.05.19
申请国别(地区):
MX
年份:
2016
代理人:
摘要：
The present invention relates to a peptide named Css54 (SEQ ID NO: 1), which comprises antibiotic activity against a range of microorganisms, 25 amino acids and a molecular weight of 2870.4 Daltons, and was isolated and purified from the venom of the scorpion Centruroides suffusus suffusus. The peptide of the invention may also be obtained by other means such as chemical synthesis or by a recombinant DNA technology. The Css54 peptide (SEQ ID NO: 1) is characterized by an alpha-linear secondary structure, which differs from the structure of other peptides, such as those having a beta sheet structure with disulfide bridges, similar to that of the beta-defensin group. The present invention further relates to pharmaceutical compositions comprising said peptide and optionally, a mixture thereof with commercial antibiotics such as kanamycin, streptomycin, isoniazid, pyrazinamide or Rifampicin.La presente invención se refiere a un péptido aislado y purificado con actividad antibiótica caracterizado por presentar una secuencia aminoacídica SEQ ID NO. 1, o cualquier modificación o mutación conservativa funcionalmente equivalente de la misma.
