BAIR, KENNETH W.,BAUMEISTER, TIMM,BUCKMELTER, ALEXANDRE J.,FELTER, KARL H.,DRAGOVICH, PETER,GOSSELIN, FRANCIS,HAN, BINGSONG,LIN, JIAN,REYNOLDS, DAVID J.,ROTH, BRUCE,SMITH, CHASE,WANG, ZHONGGUO,YUEN, P
申请号：
PE0003682013
公开号：
PE00112014A1
申请日:
2011.09.02
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to compounds and compositions for the inhibition of nampt of formula (i), where r is selected from dihidropiridopirimidina Benzothiazole, among others, naftiridina r1 is cicloalquil, aryl, heteroaryl among others R2 and R3 are H and deuterium.Preferred compounds are: N (piperidin - 4 - 1 - sulfonyl) phenyl) - 3 - (pyridin-3-yl propanamide, N - (piperidin - 4 - 1 - 2 - (sulfonyl) phenyl acetamide iloxi pyridin - 3 -, N - [4 - (piperidin 1 - sulfonyl) phenyl 1h pyrrolo (3.2 - pyridin - 2 - carboxamide, among others. Also referred to a Pharmaceutical composition. Said composition is useful in the treatment of cancer.SE REFIERE A COMPUESTOS Y COMPOSICIONES PARA LA INHIBICION DE NAMPT DE FORMULA ( I ), DONDE: R SE SELECCIONA DE BENZOTIAZOL, DIHIDROPIRIDOPIRIMIDINA, NAFTIRIDINA ENTRE OTROS R1 ES CICLOALQUIL, ARIL, HETEROARIL ENTRE OTROS R2 Y R3 SON H Y DEUTERIO. SON COMPUESTOS PREFERIDOS: N- 4-(PIPERIDIN-1-SULFONIL)FENIL -3-(PIRIDIN-3-IL PROPANAMIDA, N- 4-(PIPERIDIN-1-SULFONIL)FENIL -2-(PIRIDIN-3-ILOXI ACETAMIDA, N- 4-(PIPERIDIN-1-SULFONIL)FENIL -1H-PIRROLO 3,2-C PIRIDIN-2-CARBOXAMIDA, ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE CANCER.
