A method and system of strain gain compensation in elasticity imaging is provided. The system can include a probe (120) for transmitting ultrasonic energy into a physiology (150) of a patient (50) and receiving echoes, a display device (170), and a processor (100) operably coupled to the probe and the display device. The processor can process ultrasound imaging data associated with an applied stress of the physiology of the patient. The processor can generate a strain compensation function associated with the applied stress based on at least one of (i) user inputs based on expected results associated with a portion of the physiology, (ii) a strain compensation model generated prior to processing the ultrasound imaging data, and (iii) at least a portion of the imaging data. The processor can apply the strain compensation function to the imaging data to generate a compensated strain image. The processor can present on the display device at least one of the compensated strain image and an inverse of the compensated strain image. Other embodiments are disclosed.
