YOON, HO GEUNKR,윤호근,CHOI, KYUNG CHULKR,최경철,CHA, MIN SEOKKR,차민석,YOU, YANG HEEKR,유양희,KIM, JIN YOUNGKR,김진영
申请号：
KR1020150056243
公开号：
KR1020160125616A
申请日:
2015.04.22
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to a composition for protecting immune suppression, which comprises a citron extract. It is determined that the extract according to the present invention shows no toxicity in a cytotoxicity test (test example 1) for macrophages increases secretion of NO in a concentration-dependent manner in a test (test example 2) for determining the effect on nitric oxide induction capability increases the expression of immune activity-related cytokines, such as TNF-&alpha, IL-1&beta, IL-6 and IL-10 in a concentration-dependent manner (test example 3) increases the activity of natural killer (NK) cells (test example 4) and stimulates proliferation of spleen cells (test example 5). Thus, the extract according to the present invention activates immune functions. Therefore, it is shown that the composition according to the present invention is useful as a composition for food for treating and preventing immune suppression, health-aid food, pharmaceutical, sanitary aid, or the like.COPYRIGHT KIPO 2016본 발명은 유자 추출물을 함유하는 면역저하증 보호용 조성물에 관한 것으로, 본 발명의 추출물은 대식세포에 대한 세포독성실험(실험예 1)에서 독성을 나타내지 않았으며 산화질소(Nitric Oxide) 유도능에 미치는 영향(실험예 2)에서 NO의 분비가 농도 의존적으로 증가함을 확인하였으며 TNF-α, IL-1β, IL-6, IL-10 등의 면역능 관련 시토킨 발현(실험예 3)을 농도의존적으로 증가시킴을 확인하였으며 NK(Natual Killer) 세포 활성을 증가시키고(실험예 4) 비장세포의 증식을 촉진시키는 등(실험예 5)의 면역기능을 활성화시킴을 확인하여, 면역 저하증의 치료 및 예방용 식품, 건강기능식품, 의약품, 의약외품 등의 조성물로 유용하게 이용될 수 있음을 확인하였다.
