Obschestvo S Organichennoy Otvetstvennostyu "Semiotik"
发明人:
Bovin, Nikolay Vladimirovich,Shilova, Nadezhda Vladimirovna
申请号：
AU2010366696
公开号：
AU2010366696B2
申请日:
2010.12.30
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
The invention relates to glycan arrays with quantified levels of glycan expression and a method for fabricating thereof. The method comprises quantitatively reacting an ω-aminoalkylglycan with an activated polymer of an acrylic acid derivative to obtain glycoconjugated polymer or copolymer and covalently attaching the (co)polymer to a functionalized substrate. The glycan arrays according to the invention comprise an co-aminoalkylglycan covalently attached to a functionalized substrate via a fluorescently labeled (co)polymer of an acrylic acid derivative. The copolymer of an acrylic acid derivative may comprise fluorescein cadaverine as a fluorescent label or lysine or aminated PEG. The functionalized substrate is selected from an epoxylated and aminated glass or plastic. The invention also provides a fluorescently labeled co-aminoalkylglycan conjugated polymer of an acrylic acid derivative for use in the fabrication of glycan arrays.
