DESARBRE, ERIC,GAUCHER, BERANGERE,PAGE, MALCOLM, G., P.,ROUSSEL, PATRICK
申请号：
HK09108949.6
公开号：
HK1130688B
申请日:
2009.09.28
申请国别(地区):
HK
年份:
2013
代理人:
摘要：
Compounds of the formula II: in which R8 is of the formula Q-(X) r -CO- wherein either a) X = - CH 2 -, r = 1, Q is a pyridinium group and R7 is -SO 3 - or -OSO 3 - or b) X = -SCH 2 - and r = 1 wherein Q is e.g. 1,2,3,4-tetrazol-5-yl and R7 is -SO 3 H or -OSO 3 H or c) X = -CH 2 NH 2 -, r = 1 and Q is e.g. phenyl or a 5-6-membered heterocycle and R7 is -SO 3 H or -OSO 3 H or d) X = -NH 2 - and r = 1, wherein Q is e.g. phenyl and R7 is - SO 3 H or -OSO 3 H are beta-lactamase inhibitors. They may be used in combination with monobactams against gram-negative bacteria.
