PAO, LI HENG,鲍力恒,鮑力恒,SUN, GAO GE,孙高歌,孫高歌,LU, SHAO WEI,吕绍玮,呂紹瑋
申请号：
TW100141784
公开号：
TW201321011A
申请日:
2011.11.16
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present invention discloses a group of Chinese herbal medicine (CHM) for preventing or treating depression and neurodegeneration disease potential, which including Cortex Phellodendri, Scutellariae Radix, Rhizoma Chuanxiong, Astragali Radix, Eucommia ulmoides, Saposhnikovia divaricata, Corydalis yanhusuo as the active ingredient. These herbal medicines promote proliferation of hippocampal newborn cell in vitro and in vivo in a depression-like animal model, these herbal medicines exhibit significant antidepressant effect, anti-apoptosis effect, and modulate HPA axis。本發明係提供一種用於治療或減輕憂鬱症或神經退化性疾病之醫藥組成物,其係包含至少一種中草藥,該中草藥係選自於由黃柏(Cortex Phellodendri)、黃芩(Scutellariae Radix)、川芎(Rhizoma Chuanxiong)、黃耆(Astragali Radix)、杜仲(Eucommia ulmoides)、防風(Saposhnikovia divaricata)及延胡索(Corydalis yanhusuo)所構成之群組,且上述之群組之中草藥可促進神經幹細胞新生、調節下視丘-腦下腺-腎上腺軸或抗細胞凋亡。本發明亦提供一種用於製造治療或減輕神經退化性疾病或憂鬱症之醫藥組成物的用途,其係包含至少一種上述之中草藥,該中草藥可用於促進神經新生、調節下視丘-腦下腺-腎上腺軸或抗細胞凋亡。
