株式会社国際電気通信基礎技術研究所;ADVANCED TELECOMMUNICATIONS RESEARCH INSTITUTE INTERNATIONAL
发明人:
SATO, Narutoku,佐藤匠徳
申请号：
JPJP2017/013124
公开号：
WO2017/170803A1
申请日:
2017.03.29
申请国别(地区):
JP
年份:
2017
代理人:
摘要：
The present invention addresses the problem of providing a pharmaceutical composition or a food or beverage composition, which contains an active ingredient capable of suppressing the development of the function of Oscar protein. The present invention also addresses the problem of providing a pharmaceutical composition or a food composition, which can be used for the prevention or treatment of renal diseases. The present invention further addresses the problem of providing a pharmaceutical composition or a food or beverage composition, which can suppress the development of the function of Oscar in vivo for the purpose of suppressing the development of the function of FGF23. The present invention still further provides a method for assessing the in vivo effect of an active ingredient capable of suppressing the development of the function of Oscar protein.The above-mentioned problems can be solved by at least one member selected from the group consisting of: an antagonist of Oscar protein； a genome editing system which targets Oscar gene； at least one RNA molecule selected from the group consisting of siRNA, shRNA and miRNA each targeting Oscar mRNA, or a vector capable of expressing the RNA molecule； and an antibody which can bind specifically to Oscar protein and can suppress the function of Oscar.La présente invention traite le problème de la fourniture d'une composition pharmaceutique ou d'une composition d'aliment ou de boisson, qui contient un principe actif capable de supprimer le développement de la fonction de la protéine Oscar. La présente invention aborde également le problème de la fourniture d'une composition pharmaceutique ou d'une composition alimentaire, qui peut être utilisée pour la prévention ou le traitement de maladies rénales. La présente invention concerne en outre le problème de la fourniture d'une composition pharmaceutique ou d'une composition d'aliment ou de boisson, qui peut supprimer le développement de la fonction d'Oscar in vivo dans l
