Nissan Chemical Corporation;Kyushu University, National University Corporation
发明人:
申请号：
EP17744444.5
公开号：
EP3409291A1
申请日:
2017.01.27
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention addresses the problem of providing a method for increasing the transdermal absorption of a water-soluble drug in a simple manner without relying on the formation of a prodrug of the water-soluble drug by organic synthesis. The present invention relates to: a complex which is formed from a water-soluble active ingredient and a fat-soluble compound having an aldehyde group through an interaction capable of being dissociated in water； a transdermally absorbable composition comprising the complex, a transdermal absorption controlling agent and a fat-soluble medium； and a method for controlling the release of the water-soluble active ingredient from the complex in skin.
