The invention provides human antibodies that bind to the p40 subunit of human IL-12 and/or IL-23. The invention further provides a method of treating psoriasis in a subject by administering to a subject an antibody that binds to the p40 subunit of IL-12 and/or IL-23.本發明提供結合人類IL-12及/或IL-23之p40次單元的人類抗體。本發明進一步提供一種藉由向個體投與結合IL-12及/或IL-23之p40次單元的抗體來治療個體之牛皮癬的方法。