SALAS, JOE,KISTANOVA, ELENA,HONG, VU PHONG,MEZO, ADAM R.,PETERS, ROBERT
申请号：
CA2875247
公开号：
CA2875247A1
申请日:
2013.06.07
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention provides chimeric clotting factors comprising an activatable clotting factor and an enhancer moiety. The activatable clotting factor allows the chimeric clotting factor to be activated at the site of coagulation. The enhancer moiety can additionally improve procoagulation activities of the chimeric clotting factors. The chimeric clotting factors can further be improved by fusion to a half-life extender, which improves a pharmacokinetics property of the chimeric clotting factor. The invention also includes methods of making and methods of using these chimeric clotting factors.
