The skin external use medicine of this invention prevents the emergence of the atopic characteristic chemical burn, designates that the skin external use medicine whose skin irritation is low is offered as topic, 1) the clay, and 2 where it is denaturalized with the chemical compound which possesses 4 class amino groups) features that the polymer or the copolymer which possesses the side chain which includes organism constitution component similar structure is contained.本発明の皮膚外用剤は、アトピー性皮膚炎症の発症を予防し、皮膚刺激性の低い皮膚外用剤を提供することを課題とし、1)4級アミノ基を有する化合物で変性されたクレー、および2)生体構成成分類似構造を含む側鎖を有するポリマーまたはコポリマーを含有することを特徴とする。
