There are provided a photoacoustic image evaluation apparatus, a photoacoustic image evaluation method, a photoacoustic image evaluation program, and a photoacoustic image generation apparatus capable of easily and highly accurately checking the effect of blood vessel regeneration treatment. There are included: a photoacoustic image acquisition unit that acquires a first photoacoustic image generated at a first point in time and a second photoacoustic image generated at a second point in time before the first point in time, the first and second photoacoustic images being photoacoustic images generated by detecting photoacoustic waves generated inside a subject, who has been subjected to blood vessel regeneration treatment, by emission of light into the subject； a blood vessel regeneration index acquisition unit that acquires a blood vessel regeneration index, which indicates a state of a blood vessel by the regeneration treatment, based on a difference between a blood vessel included in the first photoacoustic image and a blood vessel included in the second photoacoustic image； and a display control unit that displays the blood vessel regeneration index on a display unit.
