Svetlana O. DORONINA,Peter D. SENTER,Brian E. TOKI,Allen J. EBENS,Toni Beth KLINE,Paul POLAKIS,Mark X. SLIWKOWSKI,Susan D. SPENCER
申请号：
HK13100725.7
公开号：
HK1173382B
申请日:
2007.05.28
申请国别(地区):
HK
年份:
2017
代理人:
摘要：
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
