Christoph Leder,Meinrad Gawaz,Melanie Ziegler,Konstantinos Stellos
申请号：
US13631497
公开号：
US20130108580A1
申请日:
2012.09.28
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to a fusion protein comprising a) a first polypeptide selected from among SDF-1 (stromal cell derived factor-1) or peptidase/protease-resistant variants or fragments thereof which have the CXCR4-/CXCR7- binding function of SDF-1 and b) a second polypeptide which is selected from among GPVI (glycoprotein VI), or the extracellular domain of GPVI, or fragments or variants of the extracellular domain of GPVI which contain the collagen binding function of GPVI, wherein the first polypeptide and the second peptide are linked to one another directly or via a linker molecule. The invention furthermore relates to the use of the fusion protein for treating diseases.
