ZOLLER, Thomas,TINTELNOT-BLOMLEY, Marina,PISSOT SOLDERMANN, Carole,SCHLAPBACH, Achim,QUANCARD, Jean,SIMIC, Oliver
申请号：
PE0023912016
公开号：
PE01892017A1
申请日:
2015.05.27
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
Refers to Derivatives of pyrazolo pyrimidine compounds of formula (i) wherein R1 is halogeno, cyano or C1 - C3 alkyl, optionally substituted by Halogen C1 - C6 R2 is alkyl, cycloalkyl C3 C6Among others, phenyl optionally substituted phenyl R is optionally substituted.Preferred compounds are (S) - 1 - (6 - (2H - 1,2,3 triazol - il - 2) - 5 - (trifluoromethyl) pyridin-3-yl) - 3 - (2 - Chloro - 5 - (1 - Methoxyethyl) pyrazolo [1,5-a] pyrimidine 6 - il) urea (S) - 1 - (2 - Chloro - 5 - (1 - Methoxyethyl) pyrazolo [1,5 - to - 6 - il] pyrimidin-2-yl) - 3 - (2 - (trifluoromethyl) pyridin-4-yl) urea among others. It also relates to a Pharmaceutical composition.These compounds are inhibitors of Protein translocation 1 Lymphoma mucosa Associated Lymphoid tissue (MALT1) being useful in the treatment of rheumatoid arthritisMultiple sclerosis, systemic lupus erythematosusSE REFIERE A COMPUESTOS DERIVADOS DE PIRAZOLO PIRIMIDINA DE FORMULA (I) DONDE R1 ES HALOGENO, CIANO O ALQUILO C1-C3 OPCIONALMENTE SUSTITUIDO CON HALOGENO R2 ES ALQUILO C1-C6, CICLOALQUILO C3-C6, FENILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS R ES FENILO OPCIONALMENTE SUSTITUIDO. SON COMPUESTOS PREFERIDOS: (S)-1-(6-(2H-1,2,3-TRIAZOL-2-IL)-5-(TRIFLUOROMETIL)PIRIDIN-3-IL)-3-(2-CLORO-7-(1-METOXIETIL)PIRAZOLO[1,5-a]PIRIMIDIN-6-IL)UREA (S)-1-(2-CLORO-7-(1-METOXIETIL)PIRAZOLO[1,5-a]PIRIMIDIN-6-IL)-3-(2-(TRIFLUOROMETIL)PIRIDIN-4-IL)-UREA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA 1 DE TRASLOCACION DE LINFOMA ASOCIADO A LA MUCOSA DE TEJIDO LINFOIDE (MALT1) SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE, ESCLEROSIS MULTIPLE, LUPUS ERITEMATOSO SISTEMICO
