Yun Sil CHANG,Won Soon PARK,So Yoon AHN,Dong Kyung SUNG
申请号：
US16478330
公开号：
US20190374581A1
申请日:
2017.10.31
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to a pharmaceutical composition for preventing or treating neonatal hypoxic ischemic encephalopathy (HIE), comprising thrombin-treated stem cells or exosomes derived therefrom as an active ingredient, and a method for producing the same. According to the present invention, the thrombin-treated stem cell or the exosome derived therefrom has an increased expression of growth factors, immunoregulatory factors, antioxidation factors, or regeneration factors compared to a group not treated with thrombin and also enhances a neuronal apoptosis inhibitory effect, and thus has an advantage in that the therapeutic effect thereof on neonatal hypoxic ischemic encephalopathy (HIE) is excellent.
