Disclosed herein is a framework for facilitating image-assisted diagnostic evaluation. In accordance with one aspect of the framework, imaging parameters used in acquiring a treatment image of a portion of patient anatomy are automatically recorded during an imaging examination. The treatment image may indicate at least one location of at least one treated site. During a follow-up examination, a follow-up image of the portion of the patient anatomy may be automatically acquired using the recorded imaging parameters. To assist evaluation of treatment results, the treatment image with the indicated location of the treated site may be overlaid over the follow-up image.