3,4-substituted pyrrolidine beta-secretase inhibitors for the treatment of alzheimers disease

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专利权人:

Shawn J. Stachel

发明人:

Shawn J. Stachel,Thomas Steele,Alessia Petrocchi

申请号：

US12747605

公开号：

US08354545B2

申请日:

2008.12.10

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The present invention is directed to 3,4-substituted pyrrolidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimers disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

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