Devices and methods for sealing staples in tissue using a plurality of adjunct segments are described herein. In one embodiment, an end effector for a surgical instrument is described that can include first and second jaws, where the first jaw has a cartridge body removably attached thereto and the cartridge body has a plurality of staple cavities configured to seat staples therein. The second jaw can have an anvil with a plurality of staple forming openings formed therein, and at least one of the first and second jaws can be movable relative to the other jaw. The end effector can also include a plurality of sealing adjunct segments coupled to one another and at least one of the first and second jaws such that a staple ejected from the cartridge body passes through one of the plurality of sealing adjunct segments and tissue disposed between the first and second jaws.
