The present invention is related to a composition for the prevention ofMycoplasma synoviaeinfection, comprising NOX, MS53-0285 or the combination thereof as active ingredients. The present composition exhibits effects in relieving the symptoms caused byMycoplasma synoviaeinfection and can be served as a useful tool for the prevention and control of poultry disease.本發明關於一種防治黴漿菌感染的組合物,其含有NOX、MS53-0285、或其組合之蛋白質作為活性成分。本發明組合物具有減輕黴漿菌感染所引發之病徵的效果,可作為家禽疾病防治的有效工具。