The present invention provides a glycopegylated G-CSF that is therapeuticallyactive and which has pharmacokinetic parameters and properties that are improvedrelative to an identical, or closely analogous, G-CSF peptide that is not glycopegylated.Furthermore, the invention provides methods for mobilizing hematopoiesisin a subject, particularly a subject who has received or will receive radiationor chemotherapy treatment. The methods and compositions of the invention canfurther be used to prevent, alleviate and treat the myelosuppressive effectssuch therapies.
