The invention provides a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt: wherein R3 is selected from the group consisting of ORA； -CHO； -C(O)C1-4alkyl； -C(O)phenyl； -O-C(O)RA； and N(RB)2； R6 is selected from certain cyclic groups defined in the specification； and the remaining groups are defined in the specification； together with a pharmaceutically acceptable carrier. Most of the compounds are novel. The invention also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity.
