Darren McMurtrie;Paul R. Fatheree;Roland Gendron;Paul Allegretti;Brooke Olson;Robert Murray McKinnell;Seok-Ki Choi;Keith Jendza
发明人:
Paul Allegretti,Seok-Ki Choi,Roland Gendron,Paul R. Fatheree,Keith Jendza,Robert Murray McKinnell,Darren McMurtrie,Brooke Olson
申请号：
US14521689
公开号：
US09150514B2
申请日:
2014.10.23
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention is directed to methods for treating hypertension or heart failure using compounds having the formula:wherein: Ar, r, Y, Z, Q, W, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. In particular embodiments, the invention uses compounds having formula IIIa, IVa, Va:These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity.
