Blood coagulation protein conjugates

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专利权人:

BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE S.A.

发明人:

TURECEK PETER,HAIDER STEFAN,SIEKMANN JUERGEN,ROTTENSTEINER HANSPETER

申请号：

NZ59805610

公开号：

NZ598056A

申请日:

2010.07.26

申请国别(地区):

NZ

年份:

2014

代理人:

摘要：

598056 Discloses a modified blood coagulation protein comprising a)Factor IX (FIX) or Factor VIII (FVIII) and b) at least one polysialic acid (PSA) containing an active aminooxy group bound to said blood coagulation protein of (a)； Wherein the blood coagulation protein has an oxime linkage between one or more oxidized carbohydrate moieties and the active aminooxy group on the PSA； wherein the protein has a specific activity of at least 50% relative to an unmodified blood coagulation protein.

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