THIYAGARAJAN, KAMALRAJ,TANGIRALA, RAGHURAM,MAISHAL, TARUN KUMAR,TORA, GEORGE O.,DLUCCA, INDAWATI,LADZIATA, VLADIMIR,GLUNZ, PETER W.
申请号：
ARP180101933
公开号：
AR112273A1
申请日:
2018.07.11
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
1. Claim 1: a compound characterized by formula (1),o uno de sus estereois meros enanti meros diastereois meros taut meros o sus sales farmac uticamente aceptables en donde el anillo A se selecciona de un heteroarilo de 5 miembros que comprende tomos de carbono y 1 - 4 hetero tomos seleccionados de NO y S y un heterociclo O R1 and R1 74919 together with the nitrogen atoms connected to them form an equation ring (2)；R² is selected from H, C₁₋₇ alkyl, C₂₋₇ alkenyl, C₂₋₇ alkynyl, - (CR¹⁰R¹⁰) ₙC₃₋₁₀ carbocycle and - (CR¹⁰R¹⁰) ₙ-4- to 15-membered heterocycle comprising carbon atoms and 1 - 4 heteroatoms selected from N, NR⁸,O and S (o)1. In these places, 1-4r8311 was used instead of tar, almond, tar, carbohydrate and heterocycle；R3,at each occurrence, is independently selected from H, halogen, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₁₋₄ alkoxy, C₁₋₄ alkylthio, C₁₋₄ haloalkyl, -CH₂OH, -OCH₂F, -OCHF₂,-OCF8323,CN, -NH₂,-NH (C₁₋₄ alkyl),-N (c832131-832424 lessor) 832222；-CO H -CH CO H -CO (C alquilo)-CO (c832131-832424 lessor)；-CH₂NH₂,-CONH₂,-CONH (c832183.31832424 lessor)；-And (c832131-832424 lease) No. 832222；-OCH CO H -NHCO (C alquilo)-NHCO₂ (C₁₋₄ alkyl),-NHSO (C alquilo)-SO₂NH₂,-C (3DNH) NH1. A carbon thyroid and a heterogeneous cycle in which pitch, acyl chloride, oxygen, pitch, carbon thyroid and foreign matter are replaced by 0-4r8313；R⁴ is selected from - (CR¹⁰R¹⁰) ₙC₃₋₁₀ carbocycle and - (CR¹⁰R¹⁰) ₙ-4-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR⁸,a. O and S (o)1. Among them, 1-4 r8311 replaced carbon thyroid and heterosexual；h. R8309es； or R2 and r83099, together forming = O； or R2 and r83099, together with carbon atoms, and combined with carbon atoms, forming a carbon thyroid or heterocycle, replaced by 1-4 r831183；R8310 should be from h, c83218331；O and S (o)1.1-4 r8311 replaces the above asphalt, aluminum, thyroid and heterocycle；Whenever you,R83099a and r8310h incomplete； r8311a,In each occurrence, H = =, o =, no =, 22；halogen, C₁₋₇ al
