SOLID FORMS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3] DIOXOL-5-YL) CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIDIN-2-YL) BENZOIC ACID

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专利权人:

VERTEX PHARMACEUTICALS INCORPORATED

发明人:

KESHAVARZ-SHOKRI, ALI,ZHANG, BEILI,KRAWIEC, MARIUSZ

申请号：

NZ58588008

公开号：

NZ585880A

申请日:

2008.12.04

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed is a crystalline polymorph of 3-(6-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid, characterized by XRPD as Form I, and a method for its preparation. Form I is characterized by one or more peaks at 15.2 to 15.6 degrees, 16.1 to 16.5 degrees, and 14.3 to 14.7 degrees in an X-ray powder diffraction obtained using Cu K alpha radiation. The crystalline polymorph is useful for treating cystic fibrosis.

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