RODGERS, JAMES D.,SHEPARD, STACEY,MADUSKUIE, THOMAS P.,WANG, HAISHENG,FALAHATPISHEH, NIKOO,RAFALSKI, MARIA,ARVANITIS, ARGYRIOS G.,STORACE, LOUIS,JALLURI, RAVI KUMAR,FRIDMAN, JORDAN S.,VADDI, KRISHNA,RODGERS JAMES D,SHEPARD STACEY,MADUSKUIE THOMAS P,WANG HAISHENG,FALAHATPISHEH NIKOO,RAFALSKI MAR
申请号：
ES06839328
公开号：
ES2373688T3
申请日:
2006.12.12
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: T, U and V are independently selected from 5 O, S, N, CR5 and NR6； wherein the ring of members formed by a carbon atom, a nitrogen atom, U, T and V is aromatic； X is N or CR4； n is 0； on is I and Y is C1-8 alkylene, C2-8 alkenylene, (CR11R12) pC (O) (CR11R12) q, (CR11R12) pC (O) NRc (CR11R12) q, (CR11R12) pC (O) O ( CR11R12) qo (CR11R12) pOC (O) (CR11R1210) q, wherein said C1-8 alkylene or C2-8 alkenylene, is optionally substituted with 1, 2 or 3 halo, OH, CN, amino, C1-4 alkylamino or C2-8 dialkylamino； Z is aryl, cycloalkyl, heteroaryl or heterocycloalkyl, each optionally substituted with 1, 2, 3, 4, 5 or 6 substituents independently selected from halo, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1- haloalkyl 4, C1-4 hydroxyalkyl, C1-4 cyanoalkyl, Cy1, CN, NO2, ORa, SRa, C (O) kb, C (O) NRcRd, C (O) ORa, OC (O) Rb, OC (O) NRcRd, NRcRd, NRcC (O) Rb, NRcC (O) NRcRd, NRcC (O) ORa, S (O) Rb, S (O) NRcRd, S (O) 2Rb, NRcS (O) 2Rb and S (O) 2NRcRd； Cy1 is independently selected from aryl, heteroaryl, cycloalkyl and heterocycloalkyl, each optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from halo, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1 haloalkyl -4, CN, NO2, ORa '' '', SRa '' '', C (O) Rb '' '', C (O) NRc '' '' Rd '' '', C (O) ORa ' '' ', OC (O) Rb' '' ', OC (O) NRc' '' 'Rd' '' ', NRc' '' 'Rd' '' ', NRc' '' 'C (O) Rb '' '', NRc '' '' C (O) ORa '' '' S (O) Rb '' '', S (O) NRc '' '' Rd '' '', S (O) 2Rb ' '' 'and S (O) 2NRc' '' 'Rd' '' '； R4 is H； R5 is H, halo, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, OR7, SR7, C (O) R8, C (O) NR9R10, C (O) OR7, OC (O) R8, OC (O) NR9R10, NR9R10, NR9C (O) R8, NR9C (O) OR7, S (O) R8, S (O) NR9R10 S (O) 2R8, NR9S (O) 2R8 or S (O) 2NRR10； R6 is H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, OR7, C (O) R8, C (O) NR9R10, C (O) OR7, S (O) R8, S (O) NR9R10, S (O) 2R8 or S (O) 2NR9R10； R 7 is H, C 1-6 a
