Andries, Koenraad Jozef Lodewijk Marcel,Koul, Anil
申请号：
NO20073823
公开号：
NO340376B1
申请日:
2007.07.23
申请国别(地区):
NO
年份:
2017
代理人:
摘要：
Use of a compound of formula (Ia) or (Ib) for the manufacture of a medicament for the treatment of latent tuberculosis, wherein the compound of formula (Ia) or (Ib) is a pharmaceutically acceptable salt, a quaternary amine, a N-oxide, a tautomeric form or a stereochemically isomeric form thereof wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl p is 1, 2, 3 or 4 R2 is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula R3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl q is zero, 1, 2, 3 or 4 R4 and R5 each independently are hydrogen, alkyl or benzyl or R4 and R5 may be taken together including the N to which they are attached R6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl or two vicinal R6 radicals may be taken together to form a bivalent radical -CH-CH-CH-CH- r is 1, 2, 3, 4 or 5 R7 is hydrogen, alkyl, Ar or Het R8 is hydrogen or alkyl R9 is oxo or R8 and R9 together form the radical -N-CH-CH-.
