The invention describes the process from 4 - [7 - (6-cyano-5-trifluoromethylpyridine-3-il) - 8-oxo-6-sulfur-5, 7-diazo [3, 4] oct-5-il] - 2-fluoro-n-methylbenzene zamida, 4 - (3 - (4-cyano-3 - (trifluoromethyl) phenyl) - 5, 5-dimethyl-4-oxo-2-thiodifluoro-dimethylamine-dibenzo-1-benzene. These compounds are effective in the treatment of nonmetabolically castrated resistant prostate cancer.La invencion se describe antiandrogenos que se selecciona de 4-[7-(6-ciano-5-trifluorometilpiridin-3-il)-8-oxo-6-tioxo-5,7-diazaspiro[3,4]oct-5-il]-2-fluoro-N-metilbenzamida, 4-(3-(4-ciano-3-(trifluorometil)fenil)-5,5-dimetil-4-oxo-2-tioxoimidazolidin-1-il)-2-fluoro-N-metilbenzamida, entre otros. Dichos compuestos son utiles en el tratamiento de cancer de prostata resistente a la castracion no metastasico
