A trajectory guide frame for use with an image-guided interventional system includes a base, an elongate device guide support, a device guide, and a locking device. The base has a patient access aperture formed therein. The elongate device guide support is secured to the base and has opposite proximal and distal ends. The distal end is positioned proximate the patient access aperture. The device guide support includes a device guide support bore therethrough that extends from the proximal end to the distal end. The device guide is configured to be removably inserted in the device guide support bore. The device guide includes a device guide lumen configured to removably receive an interventional device therethrough. The locking device is configured to secure the interventional device to the device guide and/or the device guide support. The locking device includes a gripping mechanism including: a compression gripping member defining a gripping member bore to receive the interventional device therethrough and a loading mechanism operable to deform the compression gripping member to grip the interventional device extending through the gripping member bore.
