#$%^&*AU2007231640B220120223.pdf#####HUMANIZED ANTIBODIES THAT RECOGNIZE BETA AMYLOID PEPTIDE Abstract The invention provides a humanized immunoglobulin light chain comprising 5 (i) variable region complementary determining regions (CDRs) from the I 0D5 immunoglobulin light chain variable region sequence set forth as SEQ ID NO:14, and (ii) a variable framework region from a human acceptor immunoglobulin light chain sequence, provided that at least one framework residue is substituted with the corresponding amino acid residue from the mouse 10D5 light chain variable region 10 sequence, wherein the framework residue is selected from the group consisting of: (a) a residue that non-covalently binds antigen directly (b) a residue adjacent to a CDR (c) a CDR-interacting residue and (d) a residue participating in the VL-VH interface.
