Intraoral phototherapy devices receive light from an associated light source and propagate the light into an oral cavity of a patient. The device comprises a light guide that receives light from an external light source. The light guide comprises a main body portion made of an optically transparent soft flexible biocompatible polymeric material sized and shaped to conform to contours of the oral cavity when inserted therein to direct the light to targeted regions of the oral cavity. The main body portion comprises a pair of spaced apart side wings sized and shaped to be received between a patient’s teeth and cheeks on opposite sides of the oral cavity and a center flap intermediate the side wings for transmitting and directing the light to targeted regions of the oral cavity. A controller delivers light to the light guide in a controlled manner.口內光療裝置接收來自關聯光源的光並且傳播光到病人的口腔裡。裝置包括光導，其接收來自外部光源的光。光導包括主體部分，其由光學透明之柔軟可撓性生物相容的聚合材料所做成，而尺寸做成和塑形成當插入口腔當中時符合口腔的輪廓，以指引光到口腔的目標區域。主體部分包括一對隔開的側翼，其尺寸做成和塑形成在病人的牙齒和臉頰之間被接納而在口腔的相對側上，以及主體部分包括在側翼中間的中央瓣，以傳送和指引光到口腔的目標區域。控制器以受控制的方式來傳遞光到光導。
