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Formation of cyclosporin A/cyclodextrin nanoparticles
专利权人:
Oculis ehf.
发明人:
Loftsson, Thorsteinn
申请号:
AU2016272700
公开号:
AU2016272700A1
申请日:
2016.05.27
申请国别(地区):
AU
年份:
2017
代理人:
摘要:
Methods of forming cyclosporin/cyclodextrin complex nanoparticles and microparticles, and administration of the nano- and microsuspension formed to an eye of a human or animal in the form of aqueous eye drops suitable to elicit or enhance tear formation and for treatment of diseases of the eye and surrounding areas. The aqueous eye drop composition contains cyclosporin and a mixture of α-cyclodextrin and γ-cyclodextrin as well as one or more stabilizing polymers. α-Cyclodextrin solubilizes cyclosporin while γ- cyclodextrin promotes formation of cyclosporin/cyclodextrin complex aggregates. The polymers stabilize the aqueous nano- and microsuspension.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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