Judy H. Chiao;Victoria M. Richon;William Kevin Kelly;Thomas A. Miller
发明人:
Victoria M. Richon,Judy H. Chiao,William Kevin Kelly,Thomas A. Miller
申请号：
US13276710
公开号：
US20120041067A1
申请日:
2011.10.19
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides methods of selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by administration of pharmaceutical compositions comprising potent HDAC inhibitors. The oral bioavailability of the active compounds in the pharmaceutical compositions of the present invention is surprisingly high. Moreover, the pharmaceutical compositions unexpectedly give rise to high, therapeutically effective blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo.
